I do not know if "panic" is the right word: every time I squat, when my stomach get compressed (during the descendent phase), I feel a real uncomfortable feeling. Something like a small panic attack. However, I am not scared of weightlifting and I have this feeling even when I am lifting only 80% of my 5RM. I may be wrong but I have the impression my body is reacting to some kind of compression of the diaphragm. Have you ever experience something like that? If yes, do you know what may be the cause and how to solve such an annoying problem?
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There is very likely something going on with your technique. Without more information for your specific problem, all I can do is provide a list of things to look at.
Hopefully one of these things will help point you in the right direction. While bullet 1 does apply to me, the other bullet points allow me to squat properly to depth without any breathing or panic symptoms.
Make sure your knees are spread out. If your gut is compressed by your knees, it'll contribute to your problem.
Disclaimer: I am definitely not a doctor, and have no qualification whatsoever to dispense advice. Everything that follows is a combination of Wikipedia and guesswork.
The vagus nerve passes the diaphragm and in fact has branches attached to the surface of the stomach, among other places. Since the vagus nerve has a number of jobs including involvement in regulation of heart rate, it isn't out of the question that something about your technique or your individual physiology is causing some stimulation of this nerve, which you're feeling as a heart response.
If you're concerned, definitely speak to a professional.