What's the difference? I'm looking at shake options and some contain whey isolate, some contain whey concentrate and some both.
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The main difference is in the "purity", how much lactose and fat is left with the protein after filtering. Whey isolate usually contains around 90% protein and whey concentrate is more like 70-85%.
If you have trouble digesting the lactose or are trying to minimize carbohydrate content, then whey isolate would be a good choice. Otherwise, it probably doesn't matter; just pick the concentrate since it's cheaper in terms of protein grams/dollar.