Insulin oscillations with period of 3 - 6 minutes are believed to be important for insulin sensitivity by preventing downregulation of insulin receptors.
Reading this I was wondering, if the body is using oscillations on small time scale to prevent downregulation, maybe this tells us also something about how to organize our diet on bigger time scale, too.
So I was thinking that maybe eating regularly always the same amounts of food is unnatural to our body and ultimately leads to downregulation of our metabolism. I think it could make sense, because in ancient times people couldn't eat regularly. Instead they had days when they had a whole mammut as food source and a lot of other days in a week where they had only a few berries.
So our bodies might be better adapted to cyclic eating, e.g. eating every second day 3000 kcal instead of eating 1500 kcal every day.
Are there any studies out there that could support such a line of thinking? Should we better try to eat our food or even supplements/drugs in huge amounts on a single day and then wait for one or several days until we get the next portion to prevent our body from downregulating important receptors and decreasing the metabolism?