Does anyone happen to know some sources or ideas regarding the biochemistry of working out while under socially-caused stress? This is a more in-depth follow-up, and focusing on the biochemistry, to a previous question, and so I think it deserves its own question--particularly since nothing like what I am seeking was answered in that one. (For example, I am completely uninterested here in the accepted answer there, which was to improve general health behaviors).
Elaboration: I exercised today during a period of several days of very intense and lasting socially-caused stress/anger. At the time of exercising, I was still actively angry, and quite aware of that...and thought that perhaps the exercise would do me some good to relieve some of my tension as well as just hit my regular exercise goal. The workout was a challenging (mostly inclined) treadmill workout of one hour, one that I have done a few times recently with no serious bad feelings afterward.
Tonight, though, after the workout, around dinner, I started to feel rather unwell. It was almost like coming down with a flu, just really out of sorts, warm, tired, odd feelings in my head, etc. I've felt "run over by a truck" before after hard workouts, but they are usually in the beginning of the process of getting back into shape. I know this workout is one my body was already mostly adapted to, but tonight it (possibly...maybe it was some other factor) made me feel quite unwell. I am beginning to recover now.
The Question: What is known about the biochemistry of the interaction between stress, particularly socially caused anger/frustration, and hard aerobic exercise or exercise generally?
My first pass hypothesis is that the exercise itself raises cortisol levels, but the anger/stress has already raised the basal cortisol significantly, and so the exercise-induced cortisol spike is riding on top of the social-stress caused basal level of cortisol, so the resulting cortisol levels are really high, and the poor feeling I have been having for some hours is the result of this. It may be any other biochemical molecule or molecule class, though--cytokines also come to mind.
A corollary question is whether it is unwise to exercise at these times, because of the catabolic effects of cortisol, let alone the potentially harmful effects of sustained elevated levels of glucocorticoids generally (cf. Sapolsky).