Negative reps, i.e. reps that focus on the eccentric part of the movement rather than the concentric, are supposed to result in more intensive damage to your muscle, and have also been shown to give better results than concentric-only exercise.
However, a lot of people seem to think that you shouldn't do these kinds of workouts too often, certainly not every time.
I see two different ways of doing eccentric workouts. One is to load super-one-rep-max weight and lower it, for example when squatting with safety bar, or doing negative reps for pullups when you're not strong enough to do them the regular way.
The other way would be to use slightly lower weight than usual and use very slow eccentric movements, subjectively, this feels like it's very taxing on your muscles as well, it certainly makes you more tired, but is it as effective?
In either way of doing them, how often would you suggest that you do this? Once per week?