For instance, say you're doing an HST (Hypertrophy-Specific Training) routine, and you can choose between Routine 1 ad Routine 2. In Routine 1 you would be doing 3 full-body sessions per week, and in Routine 2 you would be doing 6 upper and lower body sessions per week. Assuming that each workout is done on a separate day at roughly the same time of day, are there any advantages to one routine over the other?
S M T W T F S F F F
S M T W T F S U L U L U L
Also, I do realize that there may be psychological and time advantages in both routines; however, I am asking strictly from a physiological/physical standpoint.