It seams that there is no actual scientific research in the physiology of muscle growth. All the studies done are far from scientific since all of those are statistical studies, the results of which are questionable.

The methods of such studies have been widely criticised by many experts and also a lot of those contradict each other, for example there are studies that claim that 8-12 repetitions are optimal for muscle growth while others claim that repetition number doesn't matter. In addition to that, there are many variables that are not considered for the experiments.

Lastly, another problem of such studies, as with any type of statistical study, is the failure to explain why the results are what they are. Why does that certain number of repetitions is better, what happens inside the muscle? What are the biological processes that occur during a specific type of training.

Statistical studies are not meant to prove something but rather to either confirm a theoretically proven theory, which in those cases does not exist, or to gain some insight about which direction to head in order to prove the theory and again none of those studies does that. So my question is, are all those experiments done actually scientific or pseudoscience?

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    Could you be more specific about which studies or which individual topics of sports science you're interested in? I can't tell if you're calling the entire field a sham, or if you are critiquing our current level of understanding of hypertrophy, or the relationship between training variables and hypertrophy? And when you refer to experts, do you mean sports science experts, in which case do they not present their own evidence and theory? Aug 25, 2020 at 10:23
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    OK. Could you be more specific about which studies or which individual topics of sports science you're interested in? You're kind of hand-waving an entire field here. Aug 25, 2020 at 10:50
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    How are these studies contradictory? Is it possible you're just seeing the healthy internal back-and-forth debate that should exist in a field, especially a field where getting gold-standard data is difficult? Aug 25, 2020 at 12:21
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    @Dave: I agree that getting good data is the problem here. However I disagree with the notion that back-and-forth is healthy. In 1686 Newton proposed his second law of motion: F=ma. Then the race was on to try to disprove his hypothesis. However nobody could disprove this and the law became accepted as valid. That was until 1905 when Einstein generalized this law. However F=ma still holds true as an approximation for objects that move with v small compared to lightspeed. Within the scientific method knowledge becomes more precise it does not move back-and-forth.
    – Andy
    Aug 25, 2020 at 19:30
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    @user33976 your physics background may be misleading you as to how reductivist other scientific fields are. In many fields (medicine being the most obvious one that jumps out at me), it's not uncommon for the underlying causes of phenomena to be poorly understood, but for statistical analysis of the data (which does indeed sometimes yield contradictory results, often due to difficult-to-control variables) to be used to glean actionable insights.
    – James_pic
    Aug 26, 2020 at 9:02

3 Answers 3


Muscle growth physiology is not a pseudoscience as researchers are using scientific methods to collect and analyze data and make logical deductions.

It is true that our knowledge of muscle growth is limited and the statistical studies do not explain and prove the results, but this does not make the field non-scientific.

It would be called pseudoscience, if researchers were using methods that are either logically or scientifically wrong, which is not the case.

As far as contradicting studies are concerned, I have seen quite a few myself, this is mostly due to the fact that, as you mentioned, we can't know all the variables, and there is of course some error. This however doesn't imply that non-scientific methods were used.

I agree that statistical analysis is a poor method to actually prove a physical phenomenon, but sometimes it's the best we have, biological phenomena are extremely complex and hard to model.

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    You make good points, but when a (scientifically backed) vague correlation is used to make strong statements that are not supported by said correlation, then I think it qualifies as pseudoscience. Not saying that all people involved do, but there is a clear trend of people overselling their methods.
    – Ant
    Aug 26, 2020 at 6:43
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    One can make a much stronger statement here: statistical analysis is the standard way to test hypotheses (like whether some drug cures some disease) in medicine and other fields. It doesn't prove anything however, it typically just gives you some correlation with some confidence (meaning the two things may not be related in the way you think and there's a risk of it giving the wrong result).
    – NotThatGuy
    Aug 26, 2020 at 11:51

I do not agree with your insistence on a mechanism. In 1964 the U.S. Surgeon General published a report where he concluded that smoking causes cancer. At that time the mechanisms behind this was not understood. However there was statistical evidence in the form of a study with over 1 million subjects that showed that smoking and cancer were highly correlated. That meant that either

  • A. smoking causes cancer
  • B. cancer causes smoking
  • C. another third factor causes both smoking and cancer

B. was easily be ruled out by only including those who reported to have smoked for some time prior to getting cancer. From what I understand C. was ruled out by adjusting for plausible third factors.

However I agree with your sentiment that much of the research within this field is low quality (underfunded but performed according to scientific methodology). Looking at the metastudy linked by JustSnilloc I see some problems with many of the studies included:

1. The number of subjects is too low

3 of the studies have n = 7, 9 and 11. I doubt much trust can be placed in the results of a study with so few subjects. There is appearantly a statistical method called MBI that lets you conclude with high certanity from extremely small sample groups. This method has however been disproved and the only field where it is being used is sports science.

2. The timespan of the study is too short

For untrained subjects in particular the "newbie effect" causes hypertrophy and strength increases almost regardless of protocol to begin with.

3. It test the wrong hypothesis

It does not test the hypothesis coming from experience in the bodybuilding and strength communities: 3-5 repetitions are ideal for strength whereas 8-12 is ideal for hypertrophy. Instead it typically compares 8 repetitions with 20 repetitions. There seems to be a general problem with papers being produced by people with little or no practical weight training experience: Rippetoe: The Problem with “Exercise Science”

4. The methodology in the included studies are too different.

I also question the value of pooling many studies with slightly varying experiments in a metastudy. As an example say that study A says that 15 reps are better than 10 reps for hypertrophy in the leg press for young men. However study B says that 5 reps are better than 12 reps for hypertrophy in the bench press for women over 40. What are we to conclude from this? The statistical method used to combine all the studies seems highly complex. It also seems to involve a lot of weights and assumptions. I remember the quote "With four parameters I can fit an elephant". Meta-analysis seems to have been used to generate some strange conclusions. This paper questions the use of meta-analyses to evaluate resistance training: "In conclusion, considering the large number of variables involved in resistance training and the methodological inconsistencies in the current literature, it seems impossible to make comparisons of different studies or include different studies in the same analysis".

To me it seems that within this field a lot of reasearch is produced, but much of it is low quality or not really relevant. There may be a problem with funding. There seems to be enough funding for running journals and doing peer reviews etc. but maybe not enough funding to actually do long running experiments with a large number of subjects. Instead many resort to trying to extract more info from existing studies by doing meta-studies of questionable quality.

It may also be that such experiments have been conducted by large olympic teams in the past (USSR in particular) but never published. The result may now be common knowledge among top level coaches and they see no need to rerun the same costly experiments.

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    @Malady FWIW we know a lot more about the mechanisms of carcinogens these days. Back in the day though, the mechanism wasn't known so we only had statistics. It used to be thought that the main issue for smoking-related issues was tar content, and that's a mechanism which could easily be seen. But statistics said that low tar cigarettes didn't change the number of cancers much. So Andy isn't really right for today, but is right for when the link between smoking and cancer was made.
    – Graham
    Aug 25, 2020 at 23:43
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    I chuckled when I read B. So terrible is cancer it reaches into the past compelling one to smoke. Causality be damned.
    – DKNguyen
    Aug 26, 2020 at 1:03
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    Obligatory XKCD: Cancer causes cell phones Aug 26, 2020 at 3:30
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    @DKNguyen Don't confuse "cancer" with "diagnosed cancer". There are plenty of people with stage 4 cancer who don't realize it because they don't yet have any obvious symptoms (and no obvious "lumps" either). Suppose "lung cancer" typically started in infancy but was undiagnosible at that stage (e.g. because the invasive procedures required to diagnose it would kill more people than the disease itself).
    – alephzero
    Aug 26, 2020 at 15:17
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    RE: low number of subjects, I participated in a study like this, where muscle biopsy was used, I can tell you the procedure is invasive (and painful) and full recovery takes a few weeks, meaning a lay-man's before and after comparison is very hard to achieve because you have to either take samples very far appart in time (to allow for recovery) or physical location on the test subject (before in left bicep, after from right bicep)... you can imagine, even then there are a lot of variables including diet and habits. Establishing a reliable control is the same challenge! Aug 27, 2020 at 7:44

This is not much of a fitness question, but a question about what constitutes science and whether a specific body of research is scientific.

One of the most common distinctions between science and pseudoscience comes from Karl Popper, who is perhaps familiar to you from your physics background. For Popper, what makes science different from pseudoscience is that tests or experiments have clear point of demarcation that distinguish in a black and white way true from false. All statistical hypothesis tests are therefore scientific (because they have a clear demarcation in the critical values that distinguishes true from false unambiguously), but things like astrology and tarot reading are not.

Is research on muscle growth scientific? According to this simple presentation of Popper's view, yes - absolutely. In fact, any body of research based on null-hypothesis significance testing is, so long as the critical values are clearly specified.

There are of course other ideas, but I would recommend you to the SEP article for a better review.

Perhaps at the heart of this question is a concern about the quality of the research being conducted. Being scientific doesn't imply that the research is high quality or substantively correct. That being said, the methods being used are similar to the clinical methods used in my current field (education) and other fields in which I am familiar. I would suggest that carrying over your own field's lens of what constitutes proper research methods may not be appropriate to other fields.

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