Generally, any lifting program with progressive overload will produce hypertrophy in some manner.
It is impossible to state whether or not this (or any exercise) will produce hypertrophy without effort and progression details.
I recommend you read the "Types Of Muscle Hypertrophy" and "Training Variables And Muscle Hypertrophy" of the linked article below, from which I am including excerpts, emphasis mine.
The majority of exercise-induced hypertrophy subsequent to traditional resistance training programs results from an increase of sarcomeres and myofibrils added in parallel (135,179). When skeletal muscle is subjected to an overload stimulus, it causes perturbations in myofibers and the related extracellular matrix. This sets off a chain of myogenic events that ultimately leads to an increase in the size and amounts of the myofibrillar contractile proteins actin and myosin, and the total number of sarcomeres in parallel. This, in turn, augments the diameter of individual fibers and thereby results in an increase in muscle cross-sectional area (182).
The use of high repetitions has generally proven to be inferior to moderate and lower repetition ranges in eliciting increases in muscle hypertrophy (24,71). In the absence of artificially induced ischemia (i.e., occlusion training), a load less than approximately 65% of 1RM is not considered sufficient to promote substantial hypertrophy (115).
Whether low reps or moderate reps evoke a greater hypertrophic response has been a matter of debate, and both produce significant gains in muscle growth (24) However, there is a prevailing belief that a moderate range of approximately 6-12 reps optimizes the hypertrophic response (86,89,205).
Higher-volume, multiple-set protocols have consistently proven superior over single set protocols with respect to increased muscle hypertrophy (97,197).
As to your specific question, "Will this approach yield significant strength and size gains?", the answer is yes. It will with correct effort/intensity (>65% 1RM) and progressive overload. It may not be the optimal structure, but it will increase size and strength.
Also worth noting that research on the mechanisms and effects of sarcoplasmic hypertrophy has not reached any kind of conclusive consensus: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372125/