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During muscle hypertrophy induced by strength training, there are at least two separate processes which occur that increase muscle size and strength [1]:

  • Increased rates of muscle protein synthesis which creates more contractile proteins
  • Myonuclear accretion / addition, i.e. increase in the number of myonuclei within the muscle fibers (donated by myosatellite cells) [2]

It is well established that the following factors affect the rate of muscle protein synthesis [3]:

  • Training volume
  • Nutrition
  • Hormones (testosterone / anabolic steroids)
  • Sleep / stress levels

However, it seems that there is less research around which factors affect the rate of myonuclear addition.

For example, we know that during a cutting phase, muscle protein synthesis is reduced even in the presence of sufficient training volume because nutrition is impaired.

Assuming adequate training volume, does the impaired nutrition during a cutting phase also reduce the rate of myonuclear addition? It seems logical, but it is a completely separate process to muscle protein synthesis so it would not be safe to assume this is the case.

Which other factors affect the rate of myonuclear addition?

1: Mechanisms regulating skeletal muscle growth and atrophy

2: Role of satellite cells in muscle growth and maintenance of muscle mass

3: Muscle protein synthesis in response to nutrition and exercise

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  • Simple: - age - genetics - metabolism - diet. Oct 23, 2022 at 3:55

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