The common notion is that in order to gain muscle you must be a "calorie surplus", and in order to burn fat/lose weight you must be a in a "calorie deficit. However the cyclic-ketogenic diet claims that it allows muscle building AND fat loss? How is this possible and what is the mechanism behind it? Since surely you cannot be in a surplus and deficit at the same time?

  • 1
    I'm not familiar with that diet, but I wouldn't say that either of those common notions are exactly correct for people who take on a new form of exercise. Jun 7, 2012 at 0:35

3 Answers 3


I know someone who recently used the cyclic ketogenic diet to get good results. Based on his experience, and some of the other experiences I've read who used the approach, it's important to set your expectations appropriately.

  • The only demographic that can build muscle while losing weight is an overweight beginner. This is the same regardless of diet used.
  • Intermediate and advanced lifters will lose some maximum intensity, but their volume work would be unaffected.
  • The cyclic ketogenic diet is effective at fat loss while preserving the muscle you have acquired.

Ketosis is itself a contentious subject with researchers on both sides of the argument having studies to back up their arguments. Unfortunately, most studies use readily available sedentary people, and rarely any demographic that would match my own. I will also say that ketosis is not for everyone. I did well with it, but I have friends who didn't. I recommend a trial run without any exercise to see how you adjust. The principles behind ketosis are fairly simple and straightforward:

  • The brain needs roughly 125g of energy per day--blood glucose is the primary source. Lipids can't cross the blood-brain barrier, but glucose and ketones can.
  • When the blood glucose drops, the pancreas secretes glucagon to pull energy out of fat, muscles, and organs. The muscles and organs store glucose in the form of glycogen.
  • When there are no dietary sources of blood glucose for a prolonged period, the liver will start making ketone bodies which process the stored fat in a way that can pass the blood-brain barrier.
  • Ketone bodies cannot be reabsorbed back into the fat cells. Unused ketone bodies are urinated out.
  • About the same time that ketone bodies are created, the body also starts gluconeogenisis which is the process of converting proteins to blood glucose.

All ketogenic diets share a common trait: medium to high protein intake. The higher protein intake is necessary to provide the gluconeogenisis process a source of protein other than your muscles and organs. Additionally, if you are lifting weights, the higher protein intake is needed to repair your muscles and supply the necessary amino acids. Building muscle does take a lot of energy, but thankfully the body can use fat as a source of energy.

Ketosis based diets will completely deplete the glycogen stores in your muscles and organs by design. This has a negative impact on performance. Unchecked, high intensity exercise like weight lifting can increase the demands of energy enough where ketosis alone isn't enough to supply the energy requirements. This is a bad thing. The cyclic ketogenic diet replenishes the glycogen stores once a week. This gives you most of the week to burn fat, while keeping your energy up to meet the demands of exercise.

There have been several studies to show that there is a direct correlation between your body's maximum ability and its weight. As you lose weight, you can expect a loss of your maximum strength. Part of this is due to any cut causing a loss of lean mass as well as fat mass. That doesn't mean you are losing muscle, it very well could be some of the energy support systems that feed the muscle. However, this loss of absolute strength is relatively small compared to your fat loss. Once you reach your goal, you can rebuild that max strength.

The high fat content during the week in the cyclic ketogenic diet is sufficient to fuel your training. However, the body does do better with a periodic refeed when you are training hard.


I don't think there's very much reliable empirical evidence available on the subject. Every mention of this diet that I've seen tends to be either hyperbolic, anecdotal, or very clearly tainted by conflict-of-interest. Wikipedia's page on the subject, for example, uses as its main reference a book which advocates said diet. It's possible that the author is a verified expert who's diligently studied the matter and scrupulously documented all his sources, but my default reaction is extreme skepticism. For what it's worth, ketogenic diets have been used in the treatment of epilepsy for decades, and the medical consensus appears to be that they're generally safe. That said, there's some evidence that ketogenic diets will, if anything, impair performance during anaerobic activities due to more rapid glycogen depletion (q.v., http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524027/), though aerobic performance should not be detrimentally impacted. Given that muscle-building gains are largely dependent on anaerobic types of exercise, and that greater intensity and increased repetition to failure are generally correlated with greater gains, I would expect negative results, if anything.

As far as the hypothetical mechanism for these diets, the idea is that if the body is deprived of carbohydrates it is forced to begin to metabolize fat into fatty acids through lipolysis. Those fatty acids are then further metabolized into ketone bodies (hence, the name of the diet). Whether this actually results in improved fat loss vs. carb-containing diets while holding caloric intake constant isn't known with any certainty.


The main idea is to have two phases. Short period of carbs restrictions to lower insulin production and thus heightened lipolysys. At that time high protein content of the nutrition along with weight training must pre-serve muscles from wasting even despite lower caloric income. Then in the second phase carb refeed comes in raising metabolic rate, hormones production and
improving metabolism.

This is the idea. detailed discussion may be found in UUD2 book by Lyle McDonald.

Personally i found this approach to be too difficult for the results.

However the diet (UUD2, which is a detailed plan based on carb cycling combined with very special training) is quite effective to minimize fat gains during bulking or maintain muscles during fat loss.

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service and acknowledge you have read our privacy policy.

Not the answer you're looking for? Browse other questions tagged or ask your own question.