There seems to be some good info in http://fitness.stackexchange.com/questions/293/experiences-with-barefoot-running/386#386 for this. I'm going to disagree with Kneel Before Zod, at least partially. I am agreed that running actually barefooted can be dangerous unless you've put some time into conditioning your feet. That said, the use of minimalist running shoes means the only thing you're losing from the experience is a minor amount of tactile feedback and some toughening of the skin of your feet.

My personal experience with running barefoot is a) your stride will be different. Traditional running has your foot extending out further in front of you, usually landing on your heel. Barefoot running, try to land your foot closer to your body and absorb the shock more from front to back than back to front, b) Start slow, and listen to your feet if they start hurting, particularly if you're doing actual barefoot versus minimalist shoes, c) when wearing minimalist shoes, don't assume that they'll remove all risks of blistering, etc. Minimalist shoes are still shoes and you'll still have rub points, especially at first.