There seems to be some good info in http://fitness.stackexchange.com/questions/293/experiences-with-barefoot-running/386#386 for this. I'm going to disagree with Kneel Before Zod, at least partially. I am agreed that running actually barefooted can be dangerous unless you've put some time into conditioning your feet. That said, the use of minimalist running shoes means the only thing you're losing from the experience is a minor amount of tactile feedback and some toughening of the skin of your feet.

My personal experience with running barefoot is a) your stride will be different. Traditional running has your foot extending out further in front of you, usually landing on your heel. Barefoot running, try to land your foot closer to your body and absorb the shock more from front to back than back to front, b) Start slow, and listen to your feet if they start hurting, particularly if you're doing actual barefoot versus minimalist shoes, c) when wearing minimalist shoes, don't assume that they'll remove all risks of blistering, etc. Minimalist shoes are still shoes and you'll still have rub points, especially at first.

Updating with responses on stride length:

 - It's going to be shorter, more of a rapid series of pumping pushes than more separated bounds
 - You want your foot to land under your body, or only slightly in front.
 - The running should not feel like you're "pulling", using the friction of your feet against the ground to pull yourself forward on your front foot. Instead, you should feel like you're always pushing off of your feet to provide the motion.

There's a fairly good (if mildly vague) set of tips [here][1].


  [1]: http://xeroshoes.com/barefoot-running-tips/how-to-run-barefoot/#