This question is about something I've been experiencing consistently for some fifteen years.

If I'm training consistently in running, say putting in 8 miles a day, five days a week, I experience a "lethargy" which begins sometime in the middle of the first rest day and becomes much more intense on a second consecutive day of rest, after a full day of rest.

This is not exactly fatigue; it is something else, like a groggy, sleepy feeling. A few times I experimented with using running to make it go away and it worked. For instance going outside and doing a few wind sprints of several hundred meters --- it was like hitting some big, red "wake up" button in the brain. It's a paradox: I don't want to do anything, just lie down. But the energy is there to run explosively, and feel completely opposite afterward, like a bipolar swing.

I don't experience this if I replace running with some other endurance activity, like a decent volume and intensity of cycling. With cycling, I will be tired at the end of a bout of five days, and feel better with consecutive rest days, as one would expect.

It is definitely not a case of overtraining. The effect doesn't require a high volume or intensity of training, and as I wrote above, it increases with prolonged rest, at least over a few days.

It rather seems to resemble some kind of drug withdrawal.

Is this effect known and documented somewhere?

  • Interesting question! I observe the same with going to the gym. As long as I stick to my schedule I'll not be inclined to skip a day. The better the streak, the less I even have to think about going, it becomes a habit. But the moment I skip a session, the more likely it is a next session will be skipped. I think it might be psychological and an effect of habit building, where one failure to comply immediately sets back the habit considerably.
    – G_H
    Commented May 3, 2016 at 9:17

2 Answers 2


Finding precise studies seems to be hard, but I think we might be dealing with two factors: psychological and physiological.

On a psychological level, there is habit formation. Taking an extract from Wikipedia:

Habit formation is the process by which a behaviour, through regular repetition, becomes automatic or habitual. This is modelled as an increase in automaticity with number of repetitions up to an asymptote. This process of habit formation can be slow. Lally et al. (2010) found the average time for participants to reach the asymptote of automaticity was 66 days with a range of 18–254 days.

As the habit is forming, it can be analysed in three parts: the cue, the behavior, and the reward. The cue is the thing that causes the habit to come about, the trigger of the habitual behaviour. This could be anything that one's mind associates with that habit and one will automatically let a habit come to the surface. The behavior is the actual habit that one exhibits, and the reward, a positive feeling, therefore continues the "habit loop". A habit may initially be triggered by a goal, but over time that goal becomes less necessary and the habit becomes more automatic.

A day without running after consecutive days with running would be a break in the habit loop. Even if your habit is stated in your mind as "go running 5 times a week", that's what you believe the habit to be on a cognitive level, but subconsciously you've been conditioned to do this daily. So as a day passes without running the loop is broken and the impulse towards activity is lessened. The longer you wait, the further you are on the drop-off of the habit formation curve towards automaticity and it will once again take an act of willpower to start again. But upon successfully doing so you'll quickly move towards the previous level again; if you didn't wait too long you'll still be way better off than starting from scratch, and the downtime will in retrospect seem like a little hickup in what is otherwise a well-established habit. I think this might have some effect on that "wake-up" feeling you get when you go for a run when the lethargy is setting in. The positive effect on mood from re-establishing the habit loop would definitely have an uplifting effect. I know for one that if I spend a whole day lazing about inside watching YouTube, or spend the day going to the park, sitting in the sun and reading, the latter will leave me in a better mood and feeling more fullfilled and awake, despite both arguably having been "unproductive" leisure time.

In your case that doesn't seem to cover the whole story, though, since you mention this is specific to running and in other activities like cycling the time off actually contributes to recovery and a new-found readiness to take up the activity again. So we'd need to dig into the physiological aspects.

One possibility is that it is in fact a function of recovery. Namely, with the cycling you might be accumulating fatigue to the point where rest is needed after five consecutive days or you'll start seeing a negative return on investment (overtraining). Whereas with the running perhaps the applied volume and intensity is of a level you are already accustomed to, so without increasing these parameters recovery isn't as big a factor anymore and the habit formation becomes much more important.

This article on Wikipedia investigates the neurobiological effects of exercise: https://en.wikipedia.org/wiki/Neurobiological_effects_of_physical_exercise Of particular interest is the section "Psychological stress and cortisol".

The "stress hormone", cortisol, is a glucocorticoid that binds to glucocorticoid receptors. Psychological stress induces the release of cortisol from the adrenal gland by activating the hypothalamic–pituitary–adrenal axis (HPA axis). Short-term increases in cortisol levels are associated with adaptive cognitive improvements, such as enhanced inhibitory control; however, excessively high exposure or prolonged exposure to high levels of cortisol causes impairments in cognitive control and has neurotoxic effects in the human brain. For example, chronic psychological stress decreases BDNF expression which has detrimental effects on hippocampal volume and can lead to depression.

There might be a difference between the cortisol release for running and cycling, possibly specific to your case. Are you more accustomed to running than cycling? Perhaps cycling causes a cumulative overload whereas running no longer does this for you.

Then there is the famous "runner's high". A prolonged bout of exercise (and I'd say running 8 miles might fit the bill) can result in feelings of elation due to the release of what is known as "euphoriants", which are in fact addictive drugs. Getting these on multiple consecutive days and then denying yourself them for a few days would very much lead into withdrawal symptoms. An example of such a substance playing a role in runner's high is beta-endorphin, an analgesic which has a (substantially) higher potency than morphine.

Is this specific to running, or some sports but not including cycling? A search around online yields some anecdotal evidence from cyclists that they too can experience this same feeling of euphoria and get "in the zone". But I'd hazard a guess that given the nature of cycling versus running (relative intensity, distance, possibility of letting momentum carry you for a while or downhill) you might need longer cycling workouts compared to running to produce the same effects.

My best guesses would be that you are perhaps more accustomed to running and training specificity can have a profound effect on the produced results, or perhaps being our natural means of displacement (as opposed to cycling), running is more effective at resulting in the release of the euphoriants. But both are pure conjecture on my part.

If anyone would find some specific studies regarding this it'd be very interesting. I'm coming up empty-handed without taking more time to dig through archives with the right keywords.


I seem to have finally "debugged" this.

I'm reasonably certain that it was due to insufficient sodium. I eat too healthy, avoiding high sodium processed foods and watching the salt in cooking. Somehow I didn't suspect that as the culprit. My wife is into low sodium; she does okay, because I'm the big exerciser.

Several weeks ago, on a hunch, I started experimented with a higher sodium intake. On a Wednesday, Thursday and Friday, I drank a shot glass of soy sauce. The problem completely went away; I didn't have the strange fatigue over the weekend.

I've been going with the increased sodium intake since then and, haven't seen the problem any more for several weeks.

Also, various other problems I didn't mention also cleared up.

Placebo effect should always be suspected in cases like this, but it's just impossible; a positive attitude or belief will simply not fix this real, physical problem which makes almost every movement a chore.

I've been suffering with this for years; so I hope the information is useful to someone.

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